Halcion: Overdose and Side Effects

Majority of doctors all over the world recommend halcion as the effecting correction or remedy for patients with insomnia. Triazolam Halcion or simply triazolam, which is chemically classified as benzodiazepine, is the most prescribed sedative-hypnotic halcion. It is also considered by some as its generic name. Other triazolam drugs are Apo-triazo, Novotriolam, and Nu-Triazol. These drugs, however, are only found in Canada thus very seldom appointed.

These drugs produces CNS depression at limbic, thalamic, and hypothalamic levels of CNS. They may be mediated by neurotransmitter of aminobutyric acid or GABA.

As results, patients are sedated, there is hypnosys, the skeletal muscles are given relaxation and there are anticonvulsant activity and anxiolytic action.Young adults may be given PO 0.125 mg hs to 0.5 mg hs of these medicines while the elderlies are directed to take up PO 0.125 mg hs to 0.25 mg hs. These drugs are in tablet form and can either be 0.125 mg, 0.25 mg, or 0.5 mg.

Though rarely the case, Triazolam medicines may cause Leukopenia, (also called leukocytopenia, or leucopenia – a case wherein there is a decrease in the number of circulating white blood cells, which are called leukocytes, that combat infection in the blood thus a decrease of these white blood cells will place patients at risk of increase infection), and granulocytopenia, (reduced number of blood granulocytes, namely neutrophils, eosinophils, and basophils. The term granulocytopenia often is used synonymously with neutropenia), if wrongly given. Patients may feel a headache, lethargy, drowsiness, daytime sedation, light-headedness, anxiety, irritability, amnesia and poor coordination upon taking in of these medications as adverse reactions. They may even have nausea, vomiting, diarrhea, heartburn, abdominal pain, and constipation. Their pulse beat tends to change and they will experience chest pain.

These pills should absolutely not be given to patients with hypersensitivity to benzodiazepines, pregnancy, lactation, and intermittent porphyria. Doctors who wish to prescribe these drugs should be cautious and precautious to cases of anemia, hepatic disease, renal disease, suicidal individuals, drug abuse, elderly, psychosis, children below 15 years of age, acute narrow-angle glaucoma, and seizure disorders.

(PO: Onset 30-45 minutes)

These medication’s duration lasts for about 6 to 8 hours. They are metabolized by the liver and excreted by the kidneys (which are considered metabolites). It crosses the placenta and excreted in the breast milk. Combined with other drugs, these pills may increase the effects of cimetidine, disulfiram erythromycin, macrolides, probenicid, isoniazid, and oral contraceptive. They also increase the action of drugs such as alcohol and CNS depressants while they decrease the effects of antacids, theophylline, rifampin, and smoking.

Blood studies or blood tests that should be done before prescribing these medicines include HCT, HGB, and , RBC if there is a suspected blood dyscrasias, though such case is very rare. Hepatic studies or hepatic tests that should also be administered are AST (SGOT), ALT (SGPT) and bilirubin if the liver damage has occurred to the patient.

Doctors must also consider the patient’s mental status, his or her mood and sensorium. He or she must give importance to how the drugs affect his or her patients and take into consideration his or her patients’ memory, both long and short.

In assessing blood dyscrasias, (A general term which is used to describe any abnormality in the blood or bone marrow's cellular components, such as low white blood cell count, low red blood cell count, or low platelet count), the doctor must check if his or her patient has a fever, sore throat, bruising, rash, jauntice, and (though rarely) epistaxis.

Lastly, in prescribing such sedative-hypnotic medicines, the type of sleep problem – falling asleep and staying asleep – must be put into consideration.

These medicines must only be taken in after removal of cigarettes to prevent fires, after trying conservative measures as remedy for insomnia, one half hour or one hour before the patient’s sleeplessness, and on an empty stomach to have a fast onset or effect. It may, however, be taken in with food if GI symptoms occur.

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