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Guanabenz AcetateGuanabenze acetate or simply guanabenz is an antihypertensive central adrenergic agonist that stimulates the central adrenergic receptors in the CNS resulting in decreased sympethetic outflow from the brain with decreased peripheral resistance. Like guanfacine hydrochloride, this drug is also used in the treatment of high blood pressure. However, unlike guanficine, it is more effective when used alone, though it can also be used in combination with a thiazide type of diuretic. Guanabenz is stronger than guanfacine since it immediately begins to lower blood pressure within 60 minutes after taking a single dose and may slightly slow a patient’s pulse rate. Guanabenz acetate must be taken exactly as prescribed by the specialist. Similar to guanfacine, this kind of drug may be taken with or without food. Adults are advised to take PO 4 mg tablet every day. Though it may increase in increments of 4 to 8 mg per day, but not to exceed 32 mg each day, depending upon the discretion of the specialist who prescriobed the medicine. This medication is available in the form 4 mg and 8 mg tablets. If overdosed, the doctor must immediately administer vasopressor, (a substance that stimulates the contraction of the blood vessels, often resulting in a higher blood pressure), and the patients must discontinue drug intake. Patients receiving Guanfacine hydrochloride may experience dry mouth, constipation, cramps, nausea, diarrhea, taste change, tinnitus or a ringing noise in the ears also called ear noise, vision change, rhinitis, and nasal congestion. He or she may also feel somnolence (also known as drowsiness or hypersomnia) or a state of near-sleep, a strong desire for sleep, or sleeping unusually long periods, dizziness, headache and fatigue. Worse cases of side effect caused by this medicine are impotence, urinary incontinence and even rebound hypertension if not properly maintained. It may also cause dyspnea or difficulty in breathing may also considered as shortness of breath, dermatitis, pruritus or severe itching of an undamaged skin, and purpura, also known as bloob spots because of the purplish discolorations or bruises in the skin that is produced by small bleeding vessels near the surface of the skin, Doctors must avoid prescribing this medicine to patients suffering from hypersensitivity to guanabenz. Medical practitioners must be more cautious with pregnant women who are lactating, children below 12 years of age, and patients with severe coronary insufficiency, recent myocardial infarction, cerebrovascular disease, and severe renal and hepatic diseases. Guanabenz can make a patient drowsy and less alert, thus, driving, operating dangerous machinery, or participating in any hazardous activity that requires full mental alertness is not advisable unless both the patient and the doctor know this drug’s exact effects. A specialist must also be extra careful and cautious to patinets who have severe heart disease, stroke or related disorders, and severe liver or kidney failure. He or she (doctor) should likewise be more careful in prescribing guanbenz acetate if the patient has had a heart attack recently. AssessmentSpecialists must take into account the patients neutrophils and his or her decrease in platelets in assessing his or her medication growth. He should also evaluate the patients’ baselines in renal and liver function before the therapy begins. He also should have renal studies of the patientand watch for the increase level of their (the patients) protein, BUN, and creatanine. He always take into account the patient’s blood pressure before, during and after the treatment. Most importantly, he must assess the patient’s allergic reaction towards the medicine – if the patient still experiences rashes, fever, pruritus, and urticaria after taking in an antihistamine drug, he or she must discontinue the use of guanficine hydrochloride. |
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