Glipizide and Metformin: Side Effects

Glipizide with Metformin is a combination of two powerful anti-diabetic drugs.  This is used for the treatment of Type 2 Diabetes.  This combination is the most effective drugs, which needs to be taken with regular exercise and diet.

Glipizide with Metformin may also be used to avoid high blood sugar by regulating the function of glucose in the body.  Controlling high blood sugar will help avoid the risk of stroke, kidney disease and heart disease.  Sexual function may also be affected by high blood sugar, thus controlling this will be necessary.

What are Glipizide and Metformin?

Glipizide is in the class of drugs, which are used to help control blood sugar levels.  Glipizide stimulates the function of the pancreas to help release insulin into the blood. 

Metformin is from the class of drugs used to regulate blood sugar levels.  Metformin works to reduce the amount of glucose produced by the liver.  It also helps to reduce the amount of glucose absorbed by the body from food.  Metformin likewise help the body use the stored glucose in the body and assist in converting it into energy.  This therefore ensures that the blood sugar level will be regulated properly.

Both works to ensure management of your blood sugar levels, combining the two can be more powerful.

What are the side effects of taking Glipizide with Metformin?

• Mild side effects may happen especially during the first few weeks of taking the medication:
  • Nausea
• Abdominal pain
• Diarrhea
• Headache
• If these side effects happen later while taking Glipizide with Metformin, you should visit your health professional because it may lead to more serious medical problem.
• Rare but more serious side effects of Glipizide with Metformin are:
  • Lactic Acidosis, which is a condition where acid, builds up in the blood that can be fatal if not controlled immediately. 
• Signs of the onset of Lactic Acidosis include vomiting, metallic taste, back pain, joint pains, weight gain, sensitivity to sunlight and fever.  Immediate medical attention is necessary once you notice these symptoms.  Lightheadedness, tremor and fast heartbeat are also some of the symptoms of Lactic Acidosis.
• Hypoglycemia or very low blood sugar level.  This may be easily manageable by taking glucose tablets.  It may be hard to find glucose tablets or gels, it is therefore necessary that in order to avoid an attack of hypoglycemia, patients taking Glipizide with Metformin may need to bring hard candy or any sweet stuff anywhere they are. 

Signs and symptoms of Hypoglycemia include chills, cold sweat, dizziness, rapid heart beat, weakness hunger and may even cause fainting.

If a patient feels the onset of hypoglycemia, fruit juice, soda or even table sugar will help avoid seizure.

What to avoid if you need to take Glipizide with Metformin

• Excessive alcohol intake may predispose you to lactic acidosis.
• If you have the tendency to be allergic, ensure you discuss this with your doctor before taking Glipizide and Metformin.
• Avoid taking this combination if you need to undergo an x-ray or surgery.
• Avoid over-the-counter drugs such as those used for cough and cold relief, pain relief and weight loss.  If you feel a need for these medications, consult your doctor.  He will surely know what medication you can take if necessary.

Ensuring that your doctor understand your medical condition will help him assess your condition and may recommend if you can take this durg combination.  Additionally, you may need to read the label and other contraindication mentioned therein; this is to make sure you will be able to follow the advice from the manufacturer.  It will likewise ensure that you will benefit from taking Glipizide with Metformin.

Following the diet and exercise recommended by your health professional will be best.  This will ensure you will avoid predisposing yourself to other more serious medical condition.

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