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According to a research that was conducted by a group of scientists, it was found that a toxin can open a new avenue in treating the different brain illnesses and conditions. The researchers found that a toxin that was derived from the sea snail attaches itself with the nicotine receptors in the brain and that has shown promising effects to treat the different brain conditions.

It was in 1979 that a scientist discovered that another medical toxin known as conotixin, which is also known as Prialt was the one that got approved in about 2004 and it is this toxin that was being used to treat the cancer pain, pain associated with the injury, failed back surgery, as well as nervous system dysfunction. The new toxin that is being found is known as alpha cotoxin OmIA. This toxin is being taken from the snail known as conus omaria and that is being derived from the cone of the snail. This snail is being found from the Pacific and the Indian oceans.

The researchers are thinking that they will be able to treat the different medical conditions related to brain and those problems include the Alzheimer’s disease, depression, nicotine addiction, as well as even schizophrenia. The researchers added that they will be working on the different diseases separately and will be coming up with the treatment of the different conditions through this toxin. They said that they have to go through the different research layouts to see as to how this toxin will be able to help the different brain diseases. They said that with this toxin they are looking forward to even help people quit smoking. Wouldn’t that be amazing.

The way that this toxin works, which is the OmIA conotoxin is that it binds up with the nicotinic acetylcholine receptors, which is found on the nerve cells that are present in the brain as well as the spinal cord. The nicotinic receptors are those where the nicotine binds up with that is being smoked by an individual. This binding of the nicotine to the nicotine receptors causes the secretion of the neurotransmitters from the nerve cells and that causes an excitatory feeling by these neurotransmitters.

It is also of importance to know that there are different types of nicotinic receptors. These nicotinic receptors are alpha and beta and they both have subcategories in which the alpha has subcategories ranging from 2 till 10 and the beta receptors have categories ranging from 1-4. All these subcategories are known to perform their different functions. All the different subcategories of the receptors are known to perform their own function and that are different. The researchers were thinking that it would bring about a great influence in treating different conditions by making the different subcategories work really effectively. For example in the Parkinson’s disease the neurotransmitter dopamine decreases in amounts and thus causes a problem known as tremors. If the specific receptors are being made to secrete the neurotransmitter dopamine then this can cause the prevention of tremors in Parkinson’s disease. This then would be a big breakthrough in eradicating the different brain illnesses.

There was another comment that was made to making the smokers aware that if their child in the mother’s womb is being exposed to the smoke, then this can cause the child to have a significant variation in the structure of the nicotinic receptors and the smokers should either quit smoking for that specific period of time or should take measures where they are not smoking in home or are not making their wives smoke passively, which can directly affect the health of their child.

Now coming back on the topic, these toxins that are being found are known to bind directly to the nicotinic receptors. It is being thought that the nicotinic receptors are responsible for alcohol addiction and that with these toxins that bind to these receptors they can cause the individual to not have the craving for alcohol. It is also known that one of the nicotinic receptors are known to be related to the memory and it affects the memory if there is any problem related to these nicotinic receptors and with this toxin it is being thought that the problem of memory related to Alzheimer’s can be treated. Also the people who smoke can be made to leave the cigarettes with the help of this toxin.

Another major breakthrough that can be achieved is that the nicotinic receptors are known to secrete two other neurotransmitters known as serotonin and norepinephrine and the imbalance in these neurotransmitters result in the mood disorders and these can be used to treat the two common disorders known as depression and schizophrenia, which is going to help large number of people throughout the world.

The researchers added that this toxin will not become a drug but will be used as a tool to identify and isolate the different receptors and they will make the medicines according to that. He recommended that the receptors will be the locks whereas the medicine will be the key to open up these receptors. They added that they need to find as to the exact neurotransmitters that are present because the making of the specific drugs will be dependent on the finding of the specific receptors and their shape so a very close model key can be built in the form of a medicine that would unlock it and give the desired results.

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Cancer of the bowel is one of the biggest killer of millions of people throughout the world. The reason that this cancer becomes more lethal is the fact that it metastasizes to the different organ systems at a much faster rate. In UK alone this cancer is the cause of about 50 deaths per day from bowel cancer and there are about 18,000 men who fall victim to this cancer and about 16,000 women who fall in this category. This just needs a lot of awareness among people as to what are the different measures that they need to take to prevent the bowel cancer. Since this disease is growing at a very aggressive rate we all need to do a lot more than what we are doing now. There was a very discouraging news that came up in terms of bowel cancer.

Recently the NHS in UK proposed that the two drugs known as Avastin as well as Erbitux should not be prescribed. They said that there was insufficient evidence to support that these two drugs are helping the people who are suffering from the bowel cancer. This proposal has faced a lot of opposition of the different groups and organizations as well as a lot of people who are suffering from the bowel cancer. These people said that they just cannot think that they would have survived without the use of Avastin or Erbitux because for them these medicines are the hope and if these medicines are being taken away from them then they would not be able to live. It is similar to ask a person that he would not be getting oxygen to breathe.

A lot of people have shared that they just could not believe that this kind of proposal has been raised since there are so many evidences where people have got so much benefit from these drugs and that these medicines have been able to give them their life back. The different charitable organizations have said that these drugs are the best known option for the people who are suffering from cancer that has spread to the different organ structures. They are also saying that these drugs are also miracle drugs because they are known to increase the life expectancy of the individuals by four to six months and that is a great deal of time for a person who is to die in a day or two without it. It is really concerning that Scotland has made a similar decision as well.

It is a fact that the bowel cancers can be treated if detected early and they are not treatable if they are being detected in the later stages. The drugs Avastin and Erbitux are monoclonal antibodies and they are just similar to the biological agent such as Herceptin that is being used to treat the breast cancer. The Avastin and the Erbitux are being given to the patients in whom the cancer is being known to metastasize to the liver and the lungs and they bear a potent effect by killing the tumor cells. Avastain is also known as bevacizumab and it kills the cancer cells by simply blocking up the food supply of the tumor cells, which is blood and thus prevents the spread of the tumor from growing into the body.

There are a lot of patients who have come up protesting that this proposal must not be considered because this will just kill thousands of people just because they did not get the treatment for their illness. There are people who said that since they have been taking these medications they are feeling much much better than before and they just do not know as to what is gong to happen to them if the drug is being taken away from the market and is not available to them.

These medicines are being used as a last resort of treatment and is being given when all the other chemotherapies have failed and that is what makes a drug of hope for a lot of people who consider it the last step and a savior that separates their life from death. The drug Erbitux, which is also known as the cetuximab does its work by stopping the proliferation of the cancerous cells. These drugs have also been known to shrink the size of the tumor by about 50% in about four months’ time.

Another reason that is being discussed mostly is the cost of the drugs and that Avastin costs about 16,800 pounds whereas Erbitux costs about 11,700 pounds and that is another reason that the NHS is thinking to stop the prescription of these two drugs saying that they have scarce resources and they do not think that these medicines are having any beneficial effect on the patients at all. On the other hands the doctors who are giving these therapies to their patients are saying that they have found good results in people in whom all other forms of therapies have been useless where these two medications are proving beneficial.

People are saying that this is a very cruel step by the NHS because this can just cause loss of lives of a lot of people and people just will be dying miserably if this drug is being taken off of market or is being stopped being written as a prescription drug. The importance of the treatment through this drug can only be known by a person who is being told that he only has a week to live and that he has a chance to survive for about four to six months if he opts for Avastin and Erbitux and one can easily understand as to how important these drugs are for individuals who are standing at that stage of life and death. People are being saying that they just cannot believe that the NHS is not willing to fund the drugs that are saving the lives of millions of people who are suffering from this horrendous disease.

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Acne is a very common problem and a lot of people especially youngsters are suffering from acne problems. Well it is not only the youngsters but also the adults who are victimized by this problem. The most popular drug to treat acne had been Accutane until there have been new findings about this medicine, which state that this drug, Accutane, which is also known as isotretinoin is an anti acne drug, which is connected to cause a rise in the cholesterol levels in a higher percentage of people than was previously thought. This drug also raises the level of fats in the blood, which are triglycerides, as well as elevating the levels of the liver enzymes.

This drug has been known to increase the level of cholesterol in the body through the clinical trials, but since it is causing this problem in a large number of patients is something that is getting the people as well as the physicians really worried as it was known to be the promising drug to treat the acne conditions in a lot of people and a lot of people have found benefit from this drug.

The doctors who had been prescribing this medicine said that they have known for long that the Accutane is a medicine that raise the cholesterol levels in the blood and that they have been very cautious in prescribing this medication to the individuals who have had higher cholesterol levels. The doctors also said that when they prescribe the medication Accutane they are much more careful about the cholesterol levels and just monitor it on a consistent basis. It was also added that the level of the cholesterol goes down when the drug level goes down after it is stopped, so it is a temporary side effect of this medication and is not something that just turns out to be a permanent problem.

The concerning thing for the physicians is that the number of people who would suffer from high cholesterol levels that was suggested in the clinical trials for this drug was low and now it is being found out that the numbers have risen very sharply and a very percentage of people who are taking this medication are having higher cholesterol levels. It was also told in another study that the individuals who were using Accutane that one out of every 10 individuals was showing abnormally high levels of specific liver enzymes and these enzymes only rise in the presence of liver disease, which was concerning.

There was a study conducted on patients who were suffering from acne ranging in the ages of 13 to 50. In this study it was found that the individuals before going through the treatment of Accutane had normal levels of triglyceride, cholesterol and liver enzyme levels, but after taking the Accutane the study showed that the triglyceride levels rose in about 44 percent of the patients, high cholesterol was reported in about 31 percent of the patients and there was a rise in 11 percent of people with liver enzymes. This study also mentioned that about 92 percent participants with the liver enzyme abnormalities returned to normal once the treatment was stopped and about 80 percent of people who were suffering from high triglyceride levels and the 79 percent of people with the high cholesterol levels had a return of normal blood work when they were taken off of Accutane.

On the other hand the researchers mentioned that it is important to state that if there are even temporary elevations of cholesterol and triglycerides, this can lead to the development of the metabolic syndrome, which includes high blood pressure, cholesterol abnormalities, increased blood sugar levels etc. It is almost important to state that these metabolic syndromes ultimately lead to the development of the coronary heart disease that can ultimately lead to death.

There are doctors who are saying that they just cannot out rightly advocate to not prescribe the Accutane because that has been the wonder drug that the Dermatology has seen in years and that this study is something that just makes them cautious. They also added that they think that the benefit of this drug outweighs the risks and that this drug has cured about 89% of the patients thus far.

There is a special registry that is being made for people who are taking Accutane where the Food and Drug Administration has asked the physicians to log all their patients who are taking Accutane and that it is necessary for these patients to come and visit their doctors once a month and get their blood work up to see as to whether they have elevated cholesterol and triglyceride levels and if they are elevated then at what level do they stand at. It was also mentioned that the individuals who are getting the Accutane treatment must be observed very closely for the symptoms of depression, irritability, mood swings, as well as suicidal thoughts, aggression, psychosis etc.

If we look at the package insert of Accutane, it states that there are a quarter of patients who will suffer from the elevated triglyceride levels and about 15 percent from the elevated liver enzymes. It is really important that doctors take care at their part in prescribing this medication and on patients part they should come for regular checks to get the levels of cholesterol assessed at regular intervals.

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With a lot of advancements in the world of science, there is a new breakthrough in providing pain relief with the help of magnet therapy, which is a really new avenue in terms of providing pain relief. There have been researches conducted on a group of patients who have been suffering from post-polio syndrome. In that study a small magnet was strapped to the sensitive spots that were pretty sore and that the use of the magnet just reduced the level of pain in these individuals. In that study, which was a double blind study most of the patients were the ones who received the treatment with the magnet were the ones who had decrease in pain and on the other side the individuals who were given the placebos or the magnets that were inactive were the ones who either reported little or no improvement at all.

The researchers just analyzed the aspects of the magnet therapy in the adults who were diagnosed with the post polio syndrome and were suffering from the arthritic pain in the joints or had pain in the muscle. There were about 39 women and about 11 men who participated in the study. All these individuals were in their 50s and they had developed the post polio syndrome at the age of 40. First of all these patients were asked to identify the trigger points where they were feeling the most pain and they were asked to rate the pain on a scale of 1 to 10 where the level 10 was the worst. After that the patients were then randomly given an active and inactive magnet and that magnet was then strapped to their trigger point for a total of about 45 minutes. When the magnets were removed then the patients were asked to rate the intensity of their pain again and there were a total of about 29 participants in that study who received an active magnet. The pain that these individuals rated was of about 9 plus before the treatment and then when they wore the magnet the pain level reduced to about 4.4. On the other hand the group who received the placebo rated their pain to about 9 plus before they received the treatment and after the treatment the pain level went to about 8.4.

While explaining the magnets, the researchers said that these magnets are about less than a half inch thick and these magnets were slightly stronger than the refrigerator magnets and they were available in four set up arrangement so as to adjust in the different areas of the body, it is a rectangle which is the size of a credit card, and there was a six inch strip that was almost about two inches wide, a disc that is the size of a silver dollar and the disc, which is the size of a CD. There were about 76% of the patients who had been treated with the active magnet and they reported a decrease in pain and on the other hand only about 19% of the individuals who were treated with the placebo were the ones who felt improvement and there were no individuals who reported side effects from the treatment. The researchers said that they were not sure as to exactly why the patients did have a significant and quick pain relief. They said that the magnetic energy might be affecting the pain receptors both in the joints and in the muscles and that it lowers the sensation of pain in brain.

The researchers said that they need to do more researches in that aspect so that they are able to know as to what are the different aspects involved in the treatment of pain from the post polio syndrome and understanding that whether the magnet therapy should be recommended as an alternative to the treatment that are being prescribed as a standard mode such as physical therapy, braces, anti-inflammatory drugs, as well as muscle relaxants.
One of the physicians have made his opinion that the magnetic therapy has been under observation and there is a lot of data being collected that shows a lot of people who have used this mode of therapy have gained benefits from it. The thing that needs to be seen here is that there are two kinds of magnets that are being used, one is the pulsed electromagnet that has shown its effectiveness to treat the slow healing fractures as well as in other conditions where it has shown proven benefit, whereas on the other hand is the static magnet that is being marketed with the slogans that it increases circulation, reduces the inflammation and also gives a speedy recovery from injuries to the individuals. The physician added that there are no supportive evidences to prove the benefits of the static magnets.

There was another research conducted in which there were patients who were suffering from heel pain. In this study the patients wore molded insole that contained a magnetic foil in about 19 patients, where as other 15 patients wore the same insole but there was no magnetic foil in that. In this study there were about 60% of the people who reported improvement belonged to both the groups and it suggested that the magnetic foil just showed no benefit.

There was another study that was conducted on about 20 patients who were suffering from chronic back pain. In this study the patients were exposed to both the real and sham bipolar permanent magnets and this therapy lasted for about 6 hours a day for about 3 days a week and there was a one week gap between the treatments. There was no difference in either pain or mobility that was found between the treatments.

The physician also added that the manufacturers of these magnets claimed that these magnets increase circulation and he said that this claim is false because the magnet just did not raise the circulation of that area because if the magnet increased the circulation in that area then that area would have gone red. There was also a study that was conducted to see whether this claim was right or not that the magnet increased the circulation but it was found that the magnet did not increase the blood flow at all.

From the above mentioned information it is really important that when you are being told about the therapy that you ask your physician about the pros and cons of this therapy and that what is the percentage of improvement in pain among the different individuals suffering from pain so that you are able to make your decision that whether you are going to opt for this therapy or not. I hope you have found this article helpful and informative. I hope you overcome your pain that you are going through. Best of luck.

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Fibromyalgia is a chronic pain illness that is characterized by the widespread musculoskeletal aches and pains, includes the pain and stiffness, tenderness of the soft tissues, fatigue, as well as sleep disturbance. The most common spots where the aches and pains occur are the neck, back, shoulders, hands and the pelvic girdle, but in this illness any part of the body can be involved. The pain ranges to different level of intensities and that these differ from time to time. Another very striking evidence is that there are about 3-6 percent of the United States population who are suffering from this chronic illness. The most common gender affected by this illness are the females, but this illness also affects men as well as children.
Fibromyalgia has a tremendous impact on the lives of the individuals who are suffering from the fibromyalgia syndrome. Let us take an example that a woman who was happily married with two kids now is suffering from this illness and she has a lot of responsibilities that she has to do in an entire day, but now due to the aches and pains in her body she is unable to do that and is suffering greatly from them and thus is unable to do any of her responsibilities the way she used to and it is really affecting the lives of the entire family because now her husband has a lot to do around the house as well as go to his job and earn money to make the ends meet. If the woman has a job, she might go on a leave or has to quit that job, so this puts the family under tremendous amount of financial pressure, as well as a lot of chores that are to be done on a day to day basis. Therefore this illness just changes the entire lifestyle of the family and just puts them at increased stress.

Now we are going to look at the symptoms of the fibromyalgia, which includes pain as its first symptom. The pain of fibromyalgia is quite significant and it is present throughout the body and is chronic. This pain just does not stay at one point but can involve any part of the body. If we describe the pain of the fibromyalgia, it will be that this pain is deep and is in the muscles, it is throbbing in nature and stabbing and shooting in character. There is also involvement of the neurological symptoms that include numbness, tingling, burning and this greatly intensifies the pain of the individual. The factors that greatly increase the pain include the change in weather that includes cold and humid weather, disturbance in sleep, either excessive or decreased physical activity or no physical activity at all, as well as anxiety and stress.

Another very striking symptom of fibromyalgia is the fatigue. The fatigue of the fibromyalgia is very different from the fatigue that occurs due to strenuous activity throughout the day. The fatigue that is experienced in the fibromyalgia patients is different in terms that it drains the entire energy in an individual and one feels that they have no energy at all in them to do any of the chores or any activity and this is very much depressing for the individual that they have no energy at all to function.

Along with the above two symptoms that are described above, there is another symptom that just damages the life of these individuals and that is the sleep problem due to the pain that these individuals suffer. The pain can occur at any point in time and that this pain can get greatly intensified and can involve any part of the body and thus the individual going through such pain cannot sleep during the night and cannot maintain sleep because of the pain that they are experiencing so they are up after sleeping for a few hours and this just leaves them unrested throughout the day.

Along with these symptoms, other symptoms include irritable bowel syndrome, irritable bladder, migraines, headaches, restless legs syndrome, memory deficit, lack of concentration, dry eyes, dry mouth, anxiety, chronic depression, ringing in the ears, neurological symptoms and impairment in coordination.

It is not easy to diagnose a patient who is suffering from fibromyalgia and it is from the history that the doctors gather the diagnosis from. The sites of the tender points and the history of the pain, extent of pain, character of pain, the extent of fatigue are of a major value where the doctors understand that these symptoms are indicative of fibromyalgia. It is important to note here that it takes a longer time to determine as to whether or not the individual is suffering from fibromyalgia. If there is presence of other diseases such as lupus or rheumatoid arthritis then the diagnosis of this disease is going to get a lot difficult. There is a diagnostic criteria that needs to be met to label an individual with the fibromyalgia, which includes the widespread pain in all the four quadrants of the body for the least duration of about three months. The tenderness in about 11 out of 18 points in the areas specified for the fibromyalgic points.

Another question that just raises in the mind is that what is the cause of the fibromyalgia. As of now there is no exact mechanism to explain the cause of fibromyalgia but the researchers agree that fibromyalgia is a disorder of the central processing with the dysregulation of the neuroendocrine/neurotransmitter. The patient suffers increased pain due to the abnormal sensory processing in the central nervous system. It has also been found that genetics is also responsible for the cause of fibromyalgia. The researches are still conducted to determine as to what are the definite causes of fibromyalgia and how this can be prevented.

One must get the treatment of fibromyalgia from the physician who has a command in that problem so that the right lines are being determined so as to treat these individuals who are suffering from its aftermath. Most commonly pain is the biggest symptom of fibromyalgia and for this reason over the counter pain medications are being prescribed, which includes acetaminophen, ibuprofen. There are certain instances where the individuals do not get any benefit from the over the counter pain medications are being prescribed non-narcotic medications such as tramadol or the low dose antidepressants, which include tricyclic antidepressants, serotonin reuptake inhibitor. If there is excessive pain then the physicians give lidocaine injections in the tender points so that pain can be kept at bay.

Another very important aspect that is gaining a lot of strength these days is exercise because fibromyalgia leaves people totally incapacitated and that causes them to lay down for most of the time and because of this they lose a lot of muscle content and for that matter they need to focus on the different exercises that can help them to build their muscle framework back and that will strengthen them to perform their activities of daily living. The individuals suffering from fibromyalgia might not like to exercise but if they make it their focus to gain their strength and their life back, they can put in all their energies and can regain the strength back and can star to live a normal life.

Therefore it is very important that the individuals who are suffering from fibromyalgia contact their physician or exercise instructor who can tell them about the specific exercises that can help them gain a lot of the muscle mass back in the least possible time. I hope this article would be helpful to you and that you have gained basic information about fibromyalgia. I hope that you get well pretty soon. Best of luck.

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Depression is a problem through which a lot of individuals are going through and that if we see around ourselves, we will see that there are a lot of individuals who are going through the feeling of depression and it is something that is eating them up really bad and these individuals just slowly shut themselves up and just go through isolating themselves from their surroundings. This negative behavior just makes the people go through a lot of misery inside them and it is just that they do not share and are not involving themselves into any activity. The community that is getting really affected from the clutches of depression are the elderly and in this article we are going to discuss as to how beneficial the exercise is to treat the depression. It has also been found that the middle aged and the elderly group also seem to get a whole lot benefit in their cognitive abilities through exercise.

Another very important finding that was seen through the exercise therapy was the significant improvement in the higher mental processes of memory and the functions that are termed as the executive functions, which include planning, organization, and multi-tasking of different tasks at one time. Therefore it was seen that the exercise not only lifts the depression but also brings a great deal of improvement in the higher mental processes and that is really an amazing benefit that the individuals can get from exercising. The researchers also added that the regions of the brain where they found true effectiveness of exercise were the frontal and the pre-frontal regions. The researchers also found that there were also benefits in the attention, concentration and the psychomotor skills.

The researchers added that with exercise there might be improvement in the decline in the cognitive functioning that is most commonly associated with the process of aging and that this is something that will need further studies to clarify this process and there will be definitely studies conducted to see the relationship of the effects of exercise on the cognitive functioning of the elderly. They said that along with seeing the cognitive benefits, it is also very important to see as to what are the different mechanisms that are involved in this process. Since the exact nature of the cause of improvement is not clear, it is believed by the researchers that this improvement might be because of the improved flow of oxygen rich blood to the specific regions of the brain.

The researchers said that they know that the exercise in general improves the ability of the heart to pump the blood and that it improves the contractility of the heart and it also increases the capacity of the blood to carry the oxygen. It was also linked to the said fact that that is why the elderly individuals have improved functioning because the blood flow as well as the oxygen carrying capacity increases to the brain and this is considered to be the cause of rapid improvement in the cognitive functions and health in the elderly individuals. The researchers added that since exercise improves the blood circulation to the muscles and improves the function of the muscles, as well as the tone, so it is thought that it can also have the similar effects on the brain.

There was a study that was conducted on exercise and depression, which is known as SMILE, which is an abbreviation of Standard Medical Intervention and Long-term Exercise. In this study the researchers have followed about 156 patients who were of the ages between 50 and 77 who were diagnosed with major depressive disorder, which is also known as MDD. These individuals were divided into different groups in which one group was doing exercise, the other was on the medication and another group was on a combination of medication and exercise. The exercise group was the one who were spending about 30 minutes in which they were riding a stationary bicycle or walking or jogging three times a week. The other group was the one who were using anti-depressant, which is known as sertraline, also known by the name of Zoloft and this is a very commonly used drug that belongs to the class of anti-depressants known as the selective serotonin reuptake inhibitor.

The researchers found out after 16 weeks that the groups that were on exercise, antidepressant medication, as well as a combination of both showed that all of them had effective medication in treating major depression. The participants involved in the study were put through standard tests for depression, and they took tests to check as to what are the cognitive abilities such as memory, attention, concentration, as well as the psychomotor speed. It is to note that these tests were taken before they enrolled in the trial, as well as four months after.

When the results were compared from the 42 members who were selected in the exercise group with the 42 members who were in the medication group, they found that exercise had a very positive effect on the areas of cognitive functioning. These individuals who showed a lot of benefit to the exercise therapy were the ones who had mild depression. Those people who were suffering from moderate to severe depression were the ones who showed less improvement. The research has not stopped here, but the researchers are enrolling different individuals in another study in which the participants will be diagnosed as depressed and will be the ones who will able to exercise over the age of 50.

This research has proved great benefit to the elderly individuals and will open great avenues for a lot of facts to be unveiled so that a lot of individuals benefit from it. All these researches are a great asset and will be something that will bring hope to a lot of individuals.

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